Intracellular metal transport proteins
نویسندگان
چکیده
Metal ions are essential cofactors for functional expressions of many proteins in living organisms. In cells, several trace elements are needed to activate and stabilize enzymes, such as superoxide dismutase, metalloproteases, protein kinases, and transcriptional factors containing zinc finger proteins. Recently, intracellular metal trafficking proteins, that carry metal ions to specific target proteins, have been identified in various organisms including mammalians. Such proteins are thus called metallochaperones. This review focuses on the structural and functional characteristics of several metal transport systems, such as those of copper, iron, zinc, manganese, magnesium, and nickel.
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